Antinociceptive and anti-inflammatory effects of Toddalia asiatica (L) Lam. (Rutaceae) root extract in Swiss albino mice

Antinociceptive and anti-inflammatory effects of Toddalia asiatica (L) Lam. (Rutaceae) root extract in Swiss albino mice

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INTRODUCTION: Toddalia asiatica is a commonly used medicinal plant in East Africa for the management of pain and inflammatory conditions.The Model Truck present study investigated the antinociceptive and the anti-inflammatory effects of T.asiatica in Swiss albino mice.

METHODS: The antinociceptive and the anti-inflammatory effects of T.asiatica were investigated using formalin-induced pain test and the carrageenin-induced oedema paw.The extract solvent (vehicle), aspirin and indomethacin were employed as negative and positive controls respectively.

Eight mice were used in each experiment.RESULTS: In the early phase of the formalin test, the 100mg/kg dose showed no significant antinociceptive activity while the 200mg/kg showed significant (p 0.01) antinociceptive activity.

The 100 mg/kg dose showed highly significant antinociceptive activity (p 0.001) in the late phase of the formalin Stamping test while the 200mg/kg dose showed no significant antinociceptive activity.A reduction in carragenin induced acute inflammation paw oedema was significant (p 0.

01) following administration of 100mg/kg dose but not with the 200mg/kg dose.CONCLUSION: The present study therefore lends support to the anecdotal evidence for use of T.asiatica in the management of painful and inflammatory conditions.